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Spinal Cord
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Spinal Cord
Article . 2007 . Peer-reviewed
License: Springer TDM
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Spinal Cord
Article . 2007
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Campylobacter jejuni-induced acute transverse myelitis

Authors: Baar, I.; Jacobs, B.C.; Govers, N.; Jorens, Philippe; Parizel, Paul M.; Cras, Patrick;

Campylobacter jejuni-induced acute transverse myelitis

Abstract

Case report.University Hospital of Antwerp, tertiary referral hospital of the University of Antwerp, Edegem, Belgium.Campylobacter jejuni infection is related to various syndromes in which the peripheral nervous system is involved. An immune response is triggered through molecular mimicry between gangliosides of the peripheral nervous system and lipo-oligosaccharides of C. jejuni. We report a case of a previously healthy 17-year-old girl, who developed clinical manifestations of acute transverse myelitis (ATM) 7 days after a culture-proven C. jejuni enteritis. High titres of serum IgG antibodies to the ganglioside GM1 were found in the acute phase of disease, which decreased with clinical recovery. These antibodies cross-reacted with C. jejuni lipo-oligosaccharides, indicating that C. jejuni infections may induce ATM.Only a few cases of C. jejuni infection associated with demyelination of the central nervous system or spinal cord have been described. Physicians should be aware that C. jejuni might be another cause of transverse myelitis.

Countries
Netherlands, Belgium
Keywords

Lipopolysaccharides, EMC MM-02-72-02, Antigens, Bacterial, Adolescent, Molecular Mimicry, Brain, EMC MM-04-44-02, Enzyme-Linked Immunosorbent Assay, G(M1) Ganglioside, Cross Reactions, Myelitis, Transverse, Antibodies, Bacterial, Magnetic Resonance Imaging, Campylobacter jejuni, Bacterial Proteins, Spinal Cord, Immunoglobulin G, Campylobacter Infections, Humans, Female

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    20
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
20
Top 10%
Top 10%
Average
bronze