Distribution of vascular endothelial growth factor (VEGF) in prostate disease
Copyright policy )Distribution of vascular endothelial growth factor (VEGF) in prostate disease
Vascular endothelial growth factor (VEGF) is a heparin-binding polypeptide growth factor. It is a potent mitogen for endothelial cells. Immunohistochemical localisation of VEGF was performed on 25 moderate to poorly differentiated stage T4 M+ prostate cancer specimens and 30 benign prostatic hyperplasia (BPH) specimens. A positive result was indicated by area staining >25% and +2 or +3 staining intensity. Positive epithelial staining was observed in 50% of BPH specimens and 56% of cancer specimens, while positive stromal staining was observed in 73% of BPH specimens and 30% of cancer specimens. This may reflect an active role for stromal VEGF in the pathological process of BPH.
- King's College Hospital United Kingdom
- King's College Hospital NHS Foundation Trust United Kingdom
- King's College - North Carolina United States
Male, Vascular Endothelial Growth Factor A, Lymphokines, Vascular Endothelial Growth Factors, Prostatic Hyperplasia, Humans, Intercellular Signaling Peptides and Proteins, Prostatic Neoplasms, Endothelial Growth Factors, Immunohistochemistry
Male, Vascular Endothelial Growth Factor A, Lymphokines, Vascular Endothelial Growth Factors, Prostatic Hyperplasia, Humans, Intercellular Signaling Peptides and Proteins, Prostatic Neoplasms, Endothelial Growth Factors, Immunohistochemistry
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