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Leukocytes in tubulointerstitial inflammation

Name: Leukocytes in tubulointerstitial inflammation
Creator: Jeremy Hughes
Keywords: Inflammation, 0301 basic medicine, Mice, 03 medical and health sciences, Kidney Tubules, 0302 clinical medicine, Nephrology, Macrophages, Leukocytes, Animals

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2006Publisher:Elsevier BVJournal:Kidney International, volume 69, pages 8-10 (issn: 0085-2538,

Authors: Jeremy Hughes;

doi: 10.1038/sj.ki.5000077

pmid: 16374414

Leukocytes in tubulointerstitial inflammation

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Abstract

The work of Lange-Sperandio et al in this issue explores the differential role of beta2 integrins in promoting the macrophage infiltration characteristic of the obstructed kidneys of neonatal mice. Future work is needed to define factors that regulate macrophage death within or emigration from the kidney as well as to explore strategies to modulate macrophage phenotype. This knowledge will assist the development of novel therapeutic agents to limit injury and promote tissue repair.

Related Organizations

Georgetown University
United States
Queen's University
Canada
The Queen's Medical Research Institute
United Kingdom

Keywords

Inflammation, Mice, Kidney Tubules, Nephrology, Macrophages, Leukocytes, Animals, Macrophage-1 Antigen, Lymphocyte Function-Associated Antigen-1

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	6
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average