Oral Squamous Cell Carcinoma (OSCC) causes a severe challenge in oncology due to the lack of diagnostic devices, leading to delays in detecting the disorder. The OSCC diagnosis through histopathology demands a pathologist expert because the cellular presentation is variable and highly complex. Existing diagnostic approaches for OSCC have specific efficiency and accuracy restrictions, highlighting the necessity for more reliable techniques. The increase of deep neural networks (DNN) model and their applications in medical imaging have been instrumental in disease diagnosis and detection. Automatic detection systems using deep learning (DL) approaches show tremendous promise in investigating medical imagery with speed, efficiency, and accuracy. In terms of OSCC, this system allows the diagnostic method to be streamlined, facilitating earlier diagnosis and enhancing survival rates. Automatic analysis of histopathological image (HI) can assist in accurately detecting and identifying tumorous tissue, reducing diagnostic turnaround times and increasing the efficacy of pathologists. This study presents a Squeeze-Excitation with Hybrid Deep Learning for Oral Squamous Cell Carcinoma Recognition (SEHDL-OSCCR) on HIs. The presented SEHDL-OSCCR technique mainly focuses on detecting oral cancer (OC) using hybrid DL models. The bilateral filtering (BF) technique is initially used to remove the noise. Next, the SEHDL-OSCCR technique employs the SE-CapsNet model to recognize the feature extractors. An improved crayfish optimization algorithm (ICOA) technique is utilized to improve the performance of the SE-CapsNet model. At last, the classification of the OSCC technique is performed by employing a convolutional neural network with a bidirectional long short-term memory (CNN-BiLSTM) model. The simulation results obtained using the SEHDL-OSCCR technique are investigated using a benchmark medical image dataset. The experimental validation of the SEHDL-OSCCR technique illustrated a greater accuracy outcome of 98.75% compared to recent approaches.