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Streptococcus mitis Expressing Pneumococcal Serotype 1 Capsule

Authors: Jennifer Milucky; Robert E. Gertz; Fernanda C. Lessa; H. Keipp Talbot; Fabiana Cristina Pimenta; Jeremy D. Walston; Nadine Rouphael; +8 Authors

Streptococcus mitis Expressing Pneumococcal Serotype 1 Capsule

Abstract

AbstractStreptococcus pneumoniae’spolysaccharide capsule is an important virulence factor; vaccine-induced immunity to specific capsular polysaccharide effectively prevents disease. Serotype 1S.pneumoniaeis rarely found in healthy persons, but is highly invasive and a common cause of meningitis outbreaks and invasive disease outside of the United States. Here we show that genes for polysaccharide capsule similar to those expressed by pneumococci were commonly detected by polymerase chain reaction among upper respiratory tract samples from older US adults not carrying pneumococci. Serotype 1-specific genes were predominantly detected. In five oropharyngeal samples tested, serotype 1 gene belonging toS.mitisexpressed capsules immunologically indistinct from pneumococcal capsules. Whole genome sequencing revealed three distinctS.mitisclones, each representing acps1operon highly similar to the pneumococcalcps1reference operon. These findings raise important questions about the contribution of commensal streptococci to natural immunity against pneumococci, a leading cause of mortality worldwide.

Keywords

Virulence Factors, Gene Expression, Streptococcus mitis, Cross Reactions, Serogroup, Article, Pneumococcal Infections, Cross-Sectional Studies, Streptococcus pneumoniae, Genes, Bacterial, Gene Order, Humans, Bacterial Capsules, Phylogeny

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    41
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
41
Top 10%
Top 10%
Top 10%
Green
gold