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Hyperlipidemia, statin use and dengue severity

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 21 Nov 2018 Singapore Publisher:Springer Science and Business Media LLCJournal:Scientific Reports, volume 8 (eissn: 2045-2322,

Authors: Tsin W. Yeo; Tsin W. Yeo; Htet Lin Htun; Yee Sin Leo; David C. Lye; David C. Lye; David C. Lye; +2 Authors

doi: 10.1038/s41598-018-35334-2

pmid: 30464247

pmc: PMC6249290

Hyperlipidemia, statin use and dengue severity

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Abstract

AbstractMultiple in vitro and mice model studies suggest statins may attenuate dengue severity. However, little is known about statin use and dengue severity in adult dengue patients with hyperlipidemia. We conducted a retrospective cohort study from 2004–2008 and 2012–2013 in Tan Tock Seng Hospital, Singapore on adult dengue patients with hyperlipidemia, comparing those with and without statin usage at hospitalization in terms of primary outcome of dengue hemorrhagic fever (DHF) or shock syndrome (DSS), and severe dengue (SD). Of 13,975 subjects screened, 257 dengue patients were included; 191 (74.3%) were statin users and 66 (25.7%) were non-users. Compared with non-users, statin use was not associated with decreased risk of DHF/DSS (adjusted risk ratio [aRR] = 0.66, 95%confidence interval [CI]: 0.41–1.08, P = 0.10) and SD (aRR = 1.43, 95%CI: 0.84–2.43, P = 0.19). Therefore, statin usage had minimal effect on dengue severity in our study population in Singapore.

Country

Singapore

Related Organizations

Nanyang Technological University
Singapore
Tan Tock Seng Hospital
Singapore
National University of Singapore
Singapore
National University of Singapore Libraries
Singapore

Keywords

Adult, Male, retrospective study, very elderly, 610, Hyperlipidemias, Severity of Illness Index, Article, hydroxymethylglutaryl coenzyme A reductase inhibitor, Dengue, Mice, male, middle aged, 80 and over, hyperlipidemia, severity of illness index, Animals, Humans, animal, :Science::Medicine [DRNTU], human, mouse, Aged, Retrospective Studies, Aged, 80 and over, Singapore, adult, Dengue Severity, Middle Aged, dengue, Hospitalization, aged, female, Hyperlipidemia, pathology, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, hospitalization

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