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Nature Reviews Disease Primers
Article . 2021 . Peer-reviewed
License: Springer Nature TDM
Data sources: Crossref
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Pneumonia

Authors: Antoni Torres; Catia Cilloniz; Michael S. Niederman; Rosario Menéndez; James D. Chalmers; Richard G. Wunderink; Tom van der Poll;
Abstract

Pneumonia is a common acute respiratory infection that affects the alveoli and distal airways; it is a major health problem and associated with high morbidity and short-term and long-term mortality in all age groups worldwide. Pneumonia is broadly divided into community-acquired pneumonia or hospital-acquired pneumonia. A large variety of microorganisms can cause pneumonia, including bacteria, respiratory viruses and fungi, and there are great geographical variations in their prevalence. Pneumonia occurs more commonly in susceptible individuals, including children of <5 years of age and older adults with prior chronic conditions. Development of the disease largely depends on the host immune response, with pathogen characteristics having a less prominent role. Individuals with pneumonia often present with respiratory and systemic symptoms, and diagnosis is based on both clinical presentation and radiological findings. It is crucial to identify the causative pathogens, as delayed and inadequate antimicrobial therapy can lead to poor outcomes. New antibiotic and non-antibiotic therapies, in addition to rapid and accurate diagnostic tests that can detect pathogens and antibiotic resistance will improve the management of pneumonia.

Keywords

610, INNATE LYMPHOID-CELLS, HOSPITALIZED-PATIENTS, HOST-DEFENSE, Anti-Infective Agents, /dk/atira/pure/subjectarea/asjc/2700/2700, MEMORY T-CELLS, Humans, name=General Medicine, Child, Aged, INFECTIOUS-DISEASES-SOCIETY, Respiratory tract diseases, VENTILATOR-ASSOCIATED PNEUMONIA, PSEUDOMONAS-AERUGINOSA, COMMUNITY-ACQUIRED PNEUMONIA, Pneumonia, Anti-Bacterial Agents, Community-Acquired Infections, HYPOXEMIC RESPIRATORY-FAILURE, RISK-FACTORS, Infection

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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    528
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 0.1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 0.01%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
528
Top 0.1%
Top 1%
Top 0.01%
Green
bronze