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Nature Reviews Disease Primers
Article . 2018 . Peer-reviewed
License: Springer Nature TDM
Data sources: Crossref
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Abdominal aortic aneurysms

Authors: Rebecka Hultgren; Rebecka Hultgren; Janet T. Powell; Alain Nchimi; Alain Nchimi; Jean-Olivier Defraigne; Natzi Sakalihasan; +5 Authors

Abdominal aortic aneurysms

Abstract

An abdominal aortic aneurysm (AAA) is a localized dilatation of the infrarenal aorta. AAA is a multifactorial disease, and genetic and environmental factors play a part; smoking, male sex and a positive family history are the most important risk factors, and AAA is most common in men >65 years of age. AAA results from changes in the aortic wall structure, including thinning of the media and adventitia due to the loss of vascular smooth muscle cells and degradation of the extracellular matrix. If the mechanical stress of the blood pressure acting on the wall exceeds the wall strength, the AAA ruptures, causing life-threatening intra-abdominal haemorrhage - the mortality for patients with ruptured AAA is 65-85%. Although AAAs of any size can rupture, the risk of rupture increases with diameter. Intact AAAs are typically asymptomatic, and in settings where screening programmes with ultrasonography are not implemented, most cases are diagnosed incidentally. Modern functional imaging techniques (PET, CT and MRI) may help to assess rupture risk. Elective repair of AAA with open surgery or endovascular aortic repair (EVAR) should be considered to prevent AAA rupture, although the morbidity and mortality associated with both techniques remain non-negligible.

Country
United Kingdom
Keywords

SMOOTH-MUSCLE-CELLS, 610, General & Internal, MESENCHYMAL STEM-CELLS, Medicine, General & Internal, POSITRON-EMISSION-TOMOGRAPHY, QUALITY-OF-LIFE, Risk Factors, General & Internal Medicine, Animals, Humans, Mass Screening, INDIVIDUAL-PATIENT DATA, Ultrasonography, Science & Technology, Rupture, Spontaneous, ENDOVASCULAR REPAIR, RANDOMIZED CONTROLLED-TRIAL, 620, Disease Models, Animal, Oxidative Stress, Treatment Outcome, SURGERY PRACTICE GUIDELINES, INCREASED METABOLIC-ACTIVITY, Medicine, FINITE-ELEMENT-ANALYSIS, Tomography, X-Ray Computed, Life Sciences & Biomedicine, Aortic Aneurysm, Abdominal

  • BIP!
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    473
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 0.1%
    influence
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    Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
473
Top 0.1%
Top 1%
Top 0.1%
Green