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KRAS-G12C in the crosshairs

Name: KRAS-G12C in the crosshairs
Creator: Sarah Seton-Rogers
Keywords: Proto-Oncogene Proteins p21(ras), 0301 basic medicine, Mice, 0303 health sciences, 03 medical and health sciences, Neoplasms, Animals, Humans, Antineoplastic Agents, 3. Good health

descriptionPublicationkeyboard_double_arrow_right Article 14 Nov 2019 English Publisher:Springer Science and Business Media LLCJournal:Nature Reviews Cancer, volume 20, pages 3-3 (issn: 1474-175X, eissn: 1474-1768,

Authors: Sarah Seton-Rogers;

doi: 10.1038/s41568-019-0228-3

pmid: 31728026

KRAS-G12C in the crosshairs

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Abstract

Two papers report the discovery and preclinical analyses of two different covalent inhibitors of KRAS-G12C (AMG 510 and MRTX849) as well as the first data on the efficacy of these inhibitors in cancer patients.

Keywords

Proto-Oncogene Proteins p21(ras), Mice, Neoplasms, Animals, Humans, Antineoplastic Agents

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	32
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%