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Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-0440

descriptionPublicationkeyboard_double_arrow_right Article 29 May 2020 English Publisher:Springer Science and Business Media LLCJournal:The Journal of Antibiotics, volume 73, pages 748-755 (issn: 0021-8820, eissn: 1881-1469,

Authors: Kanji Hosoda; Hiroshi Tomoda; Ryuji Uchida; Elyza Aiman Azizah Nur; Haruka Morita; Taichi Ohshiro; Taichi Ohshiro;

doi: 10.1038/s41429-020-0327-0

pmid: 32467602

Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-0440

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Abstract

New compounds, designated voluhemins A (1) and B (2), are isolated from the culture broth of the fungal strain Volutella citrinella BF-0440 along with structurally related known NK12838 (3). Spectroscopic data, including 1D and 2D NMR, elucidated their structures. Compounds 1-3 have a common indoline-diterpene core and two additional isoprenyl moieties. Compounds 1 and 3 contain a hemiaminal unit, while 2 is O-methylated 1. Their inhibitory activities toward sterol O-acyltransferase (SOAT) 1 and 2 isozymes in SOAT1- and SOAT2-expressing Chinese hamster ovary (CHO) cells show that 2 selectively inhibits the SOAT2 isozyme.

Related Organizations

Nagoya University
Japan
Tohoku Medical and Pharmaceutical University
Japan
Kitasato University
Japan

Keywords

Cricetulus, Magnetic Resonance Spectroscopy, Molecular Structure, Hypocreales, Animals, CHO Cells, Enzyme Inhibitors, Sterol O-Acyltransferase

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