FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells
Copyright policy )FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells
The transcription factor FOXP3 has been identified as a tumour suppressor in the breast and prostate epithelia, but little is known about its specific mechanism of action. We have identified a feed-forward regulatory loop in which FOXP3 suppresses the expression of the oncogene SATB1. In particular, we demonstrate that SATB1 is not only a direct target of FOXP3 repression, but that FOXP3 also induces two miRs, miR-7 and miR-155, which specifically target the 3'-UTR of SATB1 to further regulate its expression. We conclude that FOXP3-regulated miRs form part of the mechanism by which FOXP3 prevents the transformation of the healthy breast epithelium to a cancerous phenotype. Approaches aimed at restoring FOXP3 function and the miRs it regulates could help provide new approaches to target breast cancer.
- University of Adelaide Australia
- Women's & Children's Health Research Institute Australia
- Boston Children's Hospital United States
- Centre for Cancer Biology Australia
- University of Bonn Germany
570, tumour suppressor, FOXP3, Down-Regulation, Gene Expression, Breast Neoplasms, breast cancer, SATB1, Genes, Reporter, Luciferases, Firefly, Cell Line, Tumor, Humans, Promoter Regions, Genetic, Cell Proliferation, microRNA, Forkhead Transcription Factors, Matrix Attachment Region Binding Proteins, gene regulation networks, Gene Expression Regulation, Neoplastic, MicroRNAs, Female, RNA Interference
570, tumour suppressor, FOXP3, Down-Regulation, Gene Expression, Breast Neoplasms, breast cancer, SATB1, Genes, Reporter, Luciferases, Firefly, Cell Line, Tumor, Humans, Promoter Regions, Genetic, Cell Proliferation, microRNA, Forkhead Transcription Factors, Matrix Attachment Region Binding Proteins, gene regulation networks, Gene Expression Regulation, Neoplastic, MicroRNAs, Female, RNA Interference
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