
doi: 10.1038/nsmb852
pmid: 15523480
The general preprotein translocase of the outer mitochondrial membrane (TOM complex) transports virtually all mitochondrial precursor proteins, but cannot assemble outer-membrane precursors into functional complexes. A recently discovered sorting and assembly machinery (SAM complex) is essential for integration and assembly of outer-membrane proteins, revealing unexpected connections to mitochondrial evolution and morphology.
Apoptosis, Intracellular Membranes, Models, Biological, Mitochondria, Fungal Proteins, Mitochondrial Proteins, Protein Transport, Adenosine Triphosphate, Cytosol, Humans, Molecular Chaperones, Plant Proteins
Apoptosis, Intracellular Membranes, Models, Biological, Mitochondria, Fungal Proteins, Mitochondrial Proteins, Protein Transport, Adenosine Triphosphate, Cytosol, Humans, Molecular Chaperones, Plant Proteins
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