Reversing DNA damage with a directional bias

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2004 English Publisher:Springer Science and Business Media LLCJournal:Nature Structural & Molecular Biology, volume 11, pages 688-690 (issn: 1545-9993, eissn: 1545-9985,

Copyright policy )Funded by:NIH | Structural Cell Biology o..., NIH | EUKARYOTIC DNA ALKYLATION...

Authors: Thomas J Begley; Leona D Samson;

doi: 10.1038/nsmb0804-688

Reversing DNA damage with a directional bias

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Abstract

Structures of the human O6-alkylguanine-DNA alkyltransferase bound to substrate together with biochemical analysis provide clues to substrate acquisition and recognition, as well as details of the methyl transfer reaction catalyzed by this direct DNA repair protein.

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State University of New York at Potsdam
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Massachusetts Institute of Technology
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University at Albany, State University of New York
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