Eukaryotic ribosome assembly, transport and quality control
Copyright policy )Eukaryotic ribosome assembly, transport and quality control
Eukaryotic ribosome synthesis is a complex, energy-consuming process that takes place across the nucleolus, nucleoplasm and cytoplasm and requires more than 200 conserved assembly factors. Here, we discuss mechanisms by which the ribosome assembly and nucleocytoplasmic transport machineries collaborate to produce functional ribosomes. We also highlight recent cryo-EM studies that provided unprecedented snapshots of ribosomes during assembly and quality control.
- University of Zurich Switzerland
- Institute of Biochemistry Switzerland
- Heidelberg University Germany
- ETH Zurich Switzerland
Cell Nucleus, Cytoplasm, Organelle Biogenesis, 10179 Institute of Medical Microbiology, Eukaryota, 610 Medicine & health, Biological Transport, 1315 Structural Biology, 1312 Molecular Biology, 570 Life sciences; biology, Ribosomes
Cell Nucleus, Cytoplasm, Organelle Biogenesis, 10179 Institute of Medical Microbiology, Eukaryota, 610 Medicine & health, Biological Transport, 1315 Structural Biology, 1312 Molecular Biology, 570 Life sciences; biology, Ribosomes
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