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Nature Structural & Molecular Biology
Article . 2014 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
Nature Structural & Molecular Biology
Article . 2015
Data sources: Europe PubMed Central
https://dx.doi.org/10.1038/nsm...
Article
Data sources: Microsoft Academic Graph
https://dx.doi.org/10.1038/nsm...
Article
Data sources: Microsoft Academic Graph
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PARP1 and CBP lose their footing in cancer

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2014 English Publisher:Springer Science and Business Media LLCJournal:Nature Structural & Molecular Biology, volume 21, pages 947-948 (issn: 1545-9993, eissn: 1545-9985, Copyright policy )
Authors: Gyula, Timinszky; Andreas G, Ladurner;

doi: 10.1038/nsmb.2913

pmid: 25372309

PARP1 and CBP lose their footing in cancer

Abstract

The human histone macroH2A.1.1 recruits activated PARP1 enzyme to chromatin through its poly(ADP-ribose)-binding macrodomain. New work shows that PARP1 and CBP can be displaced from chromatin in cancer cells that have lost macroH2A.1.1, thus leading to changes in histone H2B acetylation at cancer-relevant genes.

Related Organizations
Keywords

Gene Expression Regulation, Neoplastic, Histones, Transcription, Genetic, Sialoglycoproteins, Poly (ADP-Ribose) Polymerase-1, Humans, Poly(ADP-ribose) Polymerases, Peptide Fragments

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
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