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Conformational dynamics of STIM1 activation

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2013 English Publisher:Springer Science and Business Media LLCJournal:Nature Structural & Molecular Biology, volume 20, pages 918-919 (issn: 1545-9993, eissn: 1545-9985, Copyright policy )
Authors: Stefan, Feske; Murali, Prakriya;

doi: 10.1038/nsmb.2647

pmid: 23912356

pmc: PMC4384417

Conformational dynamics of STIM1 activation

Abstract

The binding of stromal interaction molecule 1 (STIM1) to ORAI calcium channels is critical for store-operated calcium entry (SOCE), a calcium influx pathway conserved among nearly all vertebrate cells. Although many major steps of this pathway are well understood, crucial details regarding the mechanism of STIM1 activation remain unclear. A study in this issue provides important new insights into the conformational changes that occur during STIM1 activation.

Related Organizations
Keywords

Models, Molecular, Membrane Glycoproteins, ORAI1 Protein, Protein Conformation, Animals, Calcium Channels, Calcium Signaling, Stromal Interaction Molecule 1, Endoplasmic Reticulum

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
43
Top 10%
Top 10%
Top 10%
bronze