
doi: 10.1038/nsmb.2402
pmid: 23037593
SecY and Sec61 translocons mediate the orderly insertion of transmembrane segments into the lipid bilayer during membrane-protein biogenesis. Reporting in this issue, Ismail et al. now use a SecM-based molecular force sensor to show that the translocon exerts a pulling force on the nascent chain that is capable of mechanical action at two distinct stages of the insertion process.
Escherichia coli Proteins, Cell Membrane, Animals, Transcription Factors
Escherichia coli Proteins, Cell Membrane, Animals, Transcription Factors
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