The structural basis for the sensing and binding of cyclic di-GMP by STING
Copyright policy )The structural basis for the sensing and binding of cyclic di-GMP by STING
STING (stimulator of interferon genes) is an essential signaling adaptor that mediates cytokine production in response to microbial invasion by directly sensing bacterial secondary messengers such as the cyclic dinucleotide bis-(3'-5')-cyclic dimeric GMP (c-di-GMP). STING's structure and its binding mechanism to cyclic dinucleotides were unknown. We report here the crystal structures of the STING cytoplasmic domain and its complex with c-di-GMP, thus providing the structural basis for understanding STING function.
- Peking University China (People's Republic of)
- Peking University China (People's Republic of)
- State Key Laboratory of Protein and Plant Gene Research China (People's Republic of)
Models, Molecular, Sequence Homology, Amino Acid, Protein Conformation, Molecular Sequence Data, Membrane Proteins, Crystallography, X-Ray, STING Protein, Humans, Amino Acid Sequence, Cyclic GMP, Protein Binding
Models, Molecular, Sequence Homology, Amino Acid, Protein Conformation, Molecular Sequence Data, Membrane Proteins, Crystallography, X-Ray, STING Protein, Humans, Amino Acid Sequence, Cyclic GMP, Protein Binding
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).206 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!