Efficiency and specificity in microRNA biogenesis
Copyright policy )Efficiency and specificity in microRNA biogenesis
Primary microRNA cleavage by the Drosha-Dgcr8 'Microprocessor' complex is critical for microRNA biogenesis. Yet, the Microprocessor may also cleave other nuclear RNAs in a nonspecific manner. We studied Microprocessor function using mathematical modeling and experiments in mouse and human tissues. We found that the autoregulatory feedback on Microprocessor expression is instrumental for balancing the efficiency and specificity of its activity by effectively tuning Microprocessor levels to those of its pri-miRNA substrate.
- Weizmann Institute of Science Israel
- Reproductive Science Center United States
- University of California, San Francisco United States
Mice, MicroRNAs, HEK293 Cells, Gene Expression Regulation, Animals, Humans, Proteins, RNA-Binding Proteins, Models, Biological, HeLa Cells
Mice, MicroRNAs, HEK293 Cells, Gene Expression Regulation, Animals, Humans, Proteins, RNA-Binding Proteins, Models, Biological, HeLa Cells
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).18 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!