The neurogenetics of alternative splicing
Copyright policy )The neurogenetics of alternative splicing
Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in mammals and is controlled by specialized RNA-binding proteins. The misregulation of splicing is implicated in multiple neurological disorders. We describe recent mouse genetic studies of alternative splicing that reveal its critical role in both neuronal development and the function of mature neurons. We discuss the challenges in understanding the extensive genetic programmes controlled by proteins that regulate splicing, both during development and in the adult brain.
- University of California, Los Angeles United States
- University of California System United States
- University of California, Riverside United States
Neurons, Alternative Splicing, Neurogenesis, Animals, Brain, Humans, Nerve Tissue Proteins, Nerve Net
Neurons, Alternative Splicing, Neurogenesis, Animals, Brain, Humans, Nerve Tissue Proteins, Nerve Net
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