A new player in the puzzle of filovirus entry
Copyright policy )A new player in the puzzle of filovirus entry
Viruses of the genera Ebolavirus and Marburgvirus are filoviruses that cause haemorrhagic fever in primates, with extremely high fatality rates. Studies have focused on elucidating how these viruses enter host cells, with the aim of developing therapeutics. The ebolavirus glycoprotein has been found to play key parts in all steps of entry. Furthermore, recent studies have identified Niemann-Pick C1 (NPC1), a protein that resides deep in the endocytic pathway, as an important host factor in this process.
- University of Virginia United States
Models, Molecular, Membrane Glycoproteins, Intracellular Signaling Peptides and Proteins, Virus Internalization, Ebolavirus, Models, Biological, Viral Envelope Proteins, Niemann-Pick C1 Protein, Humans, Receptors, Virus, Carrier Proteins
Models, Molecular, Membrane Glycoproteins, Intracellular Signaling Peptides and Proteins, Virus Internalization, Ebolavirus, Models, Biological, Viral Envelope Proteins, Niemann-Pick C1 Protein, Humans, Receptors, Virus, Carrier Proteins
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