uPAR: a versatile signalling orchestrator
Copyright policy )uPAR: a versatile signalling orchestrator
The plasminogen system has been implicated in clot lysis, wound healing, tissue regeneration, cancer and many other processes that affect health and disease. The urokinase receptor uPAR was originally thought to assist the directional invasion of migrating cells, but it is now becoming increasingly evident that this proteinase receptor elicits a plethora of cellular responses that include cellular adhesion, differentiation, proliferation and migration in a non-proteolytic fashion.
- KU Leuven Belgium
- Katholieke Universiteit Leuven Belgium
- Vita-Salute San Raffaele University Italy
Integrins, Neovascularization, Pathologic, Cell Differentiation, Receptors, Cell Surface, Models, Biological, Urokinase-Type Plasminogen Activator, Receptors, Urokinase Plasminogen Activator, Plasminogen Activators, Cell Movement, Neoplasms, Gene Targeting, Cell Adhesion, Animals, Humans, Cell Division, Signal Transduction
Integrins, Neovascularization, Pathologic, Cell Differentiation, Receptors, Cell Surface, Models, Biological, Urokinase-Type Plasminogen Activator, Receptors, Urokinase Plasminogen Activator, Plasminogen Activators, Cell Movement, Neoplasms, Gene Targeting, Cell Adhesion, Animals, Humans, Cell Division, Signal Transduction
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