The protein import motor of mitochondria
Copyright policy )The protein import motor of mitochondria
Proteins that are destined for the matrix of mitochondria are transported into this organelle by two translocases: the TOM complex, which transports proteins across the outer mitochondrial membrane; and the TIM23 complex, which gets them through the inner mitochondrial membrane. Two models have been proposed to explain how this protein-import machinery works -- a targeted Brownian ratchet, in which random motion is translated into vectorial motion, or a 'power stroke', which is exerted by a component of the import machinery. Here, we review the data for and against each model.
Protein Folding, Protein Transport, Saccharomyces cerevisiae Proteins, Protein Conformation, Molecular Motor Proteins, Mitochondrial Precursor Protein Import Complex Proteins, Membrane Proteins, Membrane Transport Proteins, Models, Biological, Mitochondria
Protein Folding, Protein Transport, Saccharomyces cerevisiae Proteins, Protein Conformation, Molecular Motor Proteins, Mitochondrial Precursor Protein Import Complex Proteins, Membrane Proteins, Membrane Transport Proteins, Models, Biological, Mitochondria
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