The 3′–5′ exonucleases
Copyright policy )The 3′–5′ exonucleases
Over the past few years, several new 3' 5' exonucleases have been identified. In vitro studies of these enzymes have uncovered much about their potential functions in vivo, and certain organisms with a defect in 3' 5' exonucleases have an increased susceptibility to cancer, especially under conditions of stress. Here, we look at not only the newly discovered enzymes, but also at the roles of other 3' 5' exonucleases in the quality control of DNA synthesis, where they act as proofreading exonucleases for DNA polymerases during DNA replication, repair and recombination.
- University of Zurich Switzerland
- Petersburg Nuclear Physics Institute Russian Federation
- Petersburg Nuclear Physics Institute United States
DNA Replication, Recombination, Genetic, Exodeoxyribonuclease V, Werner Syndrome Helicase, DNA Repair, RecQ Helicases, Molecular Sequence Data, DNA Helicases, Phosphoproteins, 10226 Department of Molecular Mechanisms of Disease, Protein Structure, Tertiary, 1307 Cell Biology, Exodeoxyribonucleases, 1312 Molecular Biology, 570 Life sciences; biology, Animals, Humans, Amino Acid Sequence, Sequence Alignment, DNA Polymerase III
DNA Replication, Recombination, Genetic, Exodeoxyribonuclease V, Werner Syndrome Helicase, DNA Repair, RecQ Helicases, Molecular Sequence Data, DNA Helicases, Phosphoproteins, 10226 Department of Molecular Mechanisms of Disease, Protein Structure, Tertiary, 1307 Cell Biology, Exodeoxyribonucleases, 1312 Molecular Biology, 570 Life sciences; biology, Animals, Humans, Amino Acid Sequence, Sequence Alignment, DNA Polymerase III
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