Phosphotyrosine-binding domains in signal transduction

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2002 English Publisher:Springer Science and Business Media LLCJournal:Nature Reviews Molecular Cell Biology, volume 3, pages 177-186 (issn: 1471-0072, eissn: 1471-0080,

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Authors: Michael B, Yaffe;

doi: 10.1038/nrm759

pmid: 11994738

Phosphotyrosine-binding domains in signal transduction

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Abstract

Protein phosphorylation provides molecular control of complex physiological events within cells. In many cases, phosphorylation on specific amino acids directly controls the assembly of multi-protein complexes by recruiting phospho-specific binding modules. Here, the function, structure, and cell biology of phosphotyrosine-binding domains is discussed.

Related Organizations

Center for Cancer Research
United States
National Cancer Institute
United States
Massachusetts Institute of Technology
United States

Keywords

Models, Molecular, Binding Sites, Ligands, Models, Biological, Protein Structure, Tertiary, src Homology Domains, Animals, Humans, Receptors, Growth Factor, Phosphotyrosine, Signal Transduction

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