Transcriptional regulation of hepatic lipogenesis
Copyright policy )Transcriptional regulation of hepatic lipogenesis
Fatty acid and fat synthesis in the liver is a highly regulated metabolic pathway that is important for very low-density lipoprotein (VLDL) production and thus energy distribution to other tissues. Having common features at their promoter regions, lipogenic genes are coordinately regulated at the transcriptional level. Transcription factors, such as upstream stimulatory factors (USFs), sterol regulatory element-binding protein 1C (SREBP1C), liver X receptors (LXRs) and carbohydrate-responsive element-binding protein (ChREBP) have crucial roles in this process. Recently, insights have been gained into the signalling pathways that regulate these transcription factors. After feeding, high blood glucose and insulin levels activate lipogenic genes through several pathways, including the DNA-dependent protein kinase (DNA-PK), atypical protein kinase C (aPKC) and AKT-mTOR pathways. These pathways control the post-translational modifications of transcription factors and co-regulators, such as phosphorylation, acetylation or ubiquitylation, that affect their function, stability and/or localization. Dysregulation of lipogenesis can contribute to hepatosteatosis, which is associated with obesity and insulin resistance.
- University of California, San Francisco United States
- University of California, Berkeley United States
Transcription, Genetic, Lipoproteins, DNA-Activated Protein Kinase, Lipoproteins, VLDL, Mice, Genetic, Animals, Protein Processing, Protein Kinase C, Liver X Receptors, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Lipogenesis, TOR Serine-Threonine Kinases, Fatty Acids, Post-Translational, Nuclear Proteins, Orphan Nuclear Receptors, Gene Expression Regulation, Liver, Upstream Stimulatory Factors, Sterol Regulatory Element Binding Protein 1, VLDL, Transcription, Protein Processing, Post-Translational, Proto-Oncogene Proteins c-akt, Signal Transduction, Transcription Factors
Transcription, Genetic, Lipoproteins, DNA-Activated Protein Kinase, Lipoproteins, VLDL, Mice, Genetic, Animals, Protein Processing, Protein Kinase C, Liver X Receptors, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Lipogenesis, TOR Serine-Threonine Kinases, Fatty Acids, Post-Translational, Nuclear Proteins, Orphan Nuclear Receptors, Gene Expression Regulation, Liver, Upstream Stimulatory Factors, Sterol Regulatory Element Binding Protein 1, VLDL, Transcription, Protein Processing, Post-Translational, Proto-Oncogene Proteins c-akt, Signal Transduction, Transcription Factors
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