DNA methylation pathways and their crosstalk with histone methylation
Copyright policy )DNA methylation pathways and their crosstalk with histone methylation
Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be established at specific regions of the genome and then maintained at these sites through cell division. Protein structural domains that specifically recognize methylated DNA and methylated histones are key for targeting enzymes that catalyse these marks to appropriate genome sites. Genetic, genomic, structural and biochemical data reveal connections between these two epigenetic marks, and these domains mediate much of the crosstalk.
- University of California, Los Angeles United States
- Chinese Academy of Sciences China (People's Republic of)
- Memorial Sloan Kettering Cancer Center United States
- Shanghai Institutes for Biological Sciences China (People's Republic of)
- University of California United States
DNA (Cytosine-5-)-Methyltransferase 1, Models, Molecular, Biomedical and clinical sciences, Protein Conformation, Ubiquitin-Protein Ligases, Bioinformatics and Computational Biology, Plant Biology, Medical and Health Sciences, Epigenesis, Genetic, Histones, Genetic, Models, Genetics, Animals, Humans, DNA (Cytosine-5-)-Methyltransferases, Protein Processing, Post-Translational, Molecular, Health sciences, Biological Sciences, DNA Methylation, Biological sciences, CCAAT-Enhancer-Binding Proteins, Biochemistry and Cell Biology, Generic health relevance, Protein Processing, Post-Translational, Epigenesis, Developmental Biology, Protein Binding
DNA (Cytosine-5-)-Methyltransferase 1, Models, Molecular, Biomedical and clinical sciences, Protein Conformation, Ubiquitin-Protein Ligases, Bioinformatics and Computational Biology, Plant Biology, Medical and Health Sciences, Epigenesis, Genetic, Histones, Genetic, Models, Genetics, Animals, Humans, DNA (Cytosine-5-)-Methyltransferases, Protein Processing, Post-Translational, Molecular, Health sciences, Biological Sciences, DNA Methylation, Biological sciences, CCAAT-Enhancer-Binding Proteins, Biochemistry and Cell Biology, Generic health relevance, Protein Processing, Post-Translational, Epigenesis, Developmental Biology, Protein Binding
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