Satellite cells, the engines of muscle repair

descriptionPublicationkeyboard_double_arrow_right Article 21 Dec 2011 English Publisher:Springer Science and Business Media LLCJournal:Nature Reviews Molecular Cell Biology, volume 13, pages 127-133 (issn: 1471-0072, eissn: 1471-0080,

Copyright policy )Funded by:CIHR | unidentified

Authors: Yu Xin, Wang; Michael A, Rudnicki;

doi: 10.1038/nrm3265

pmid: 22186952

Satellite cells, the engines of muscle repair

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Abstract

Satellite cells are a heterogeneous population of stem and progenitor cells that are required for the growth, maintenance and regeneration of skeletal muscle. The transcription factors paired-box 3 (PAX3) and PAX7 have essential and overlapping roles in myogenesis. PAX3 acts to specify embryonic muscle precursors, whereas PAX7 enforces the satellite cell myogenic programme while maintaining the undifferentiated state. Recent experiments have suggested that PAX7 is dispensable in adult satellite cells. However, these findings are controversial, and the issue remains unresolved.

Related Organizations

University of Ottawa
Canada
The Ottawa Hospital Research Institute
Canada

Keywords

Adult, Wound Healing, Satellite Cells, Skeletal Muscle, Embryonic Development, Cell Differentiation, Hypertrophy, Muscle Development, Models, Biological, Animals, Humans, Paired Box Transcription Factors, Regeneration, Growth and Development, Muscle, Skeletal

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