publication . Article . 2006

SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton

Yonatan B Tzur; Katherine L. Wilson; Yosef Gruenbaum;
Open Access
  • Published: 23 Aug 2006 Journal: Nature Reviews Molecular Cell Biology, volume 7, pages 782-788 (issn: 1471-0072, eissn: 1471-0080, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
The novel SUN-domain family of nuclear envelope proteins interacts with various KASH-domain partners to form SUN-domain-dependent 'bridges' across the inner and outer nuclear membranes. These bridges physically connect the nucleus to every major component of the cytoskeleton. SUN-domain proteins have diverse roles in nuclear positioning, centrosome localization, germ-cell development, telomere positioning and apoptosis. By serving both as mechanical adaptors and nuclear envelope receptors, we propose that SUN-domain proteins connect cytoplasmic and nucleoplasmic activities.
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Subjects
Medical Subject Headings: integumentary system
free text keywords: Cell Biology, Molecular Biology, Cytoplasm, Nucleus, medicine.anatomical_structure, medicine, Cytoskeleton, Centrosome localization, SUN domain, Telomere, Biology, Cell biology
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