The multifaceted mismatch-repair system
Copyright policy )The multifaceted mismatch-repair system
By removing biosynthetic errors from newly synthesized DNA, mismatch repair (MMR) improves the fidelity of DNA replication by several orders of magnitude. Loss of MMR brings about a mutator phenotype, which causes a predisposition to cancer. But MMR status also affects meiotic and mitotic recombination, DNA-damage signalling, apoptosis and cell-type-specific processes such as class-switch recombination, somatic hypermutation and triplet-repeat expansion. This article reviews our current understanding of this multifaceted DNA-repair system in human cells.
- University of Zurich Switzerland
Exonucleases, Models, Molecular, DNA Repair, Base Pair Mismatch, 10061 Institute of Molecular Cancer Research, Drug Resistance, 1307 Cell Biology, Proliferating Cell Nuclear Antigen, 1312 Molecular Biology, Animals, Humans, 570 Life sciences; biology
Exonucleases, Models, Molecular, DNA Repair, Base Pair Mismatch, 10061 Institute of Molecular Cancer Research, Drug Resistance, 1307 Cell Biology, Proliferating Cell Nuclear Antigen, 1312 Molecular Biology, Animals, Humans, 570 Life sciences; biology
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).1K popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 0.1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 0.1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%
Citations provided by BIP!Popularity provided by BIP!