Communicating with Hedgehogs

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2005 English Publisher:Springer Science and Business Media LLCJournal:Nature Reviews Molecular Cell Biology, volume 6, pages 306-317 (issn: 1471-0072, eissn: 1471-0080,

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Authors: Joan E, Hooper; Matthew P, Scott;

doi: 10.1038/nrm1622

pmid: 15803137

Communicating with Hedgehogs

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Abstract

Signalling by secreted Hedgehog (Hh) proteins is important for the development of many tissues and organs. Damage to components of the Hh signal-transduction pathway can lead to birth defects and cancer. The Hh proteins are distributed in tissues in a gradient, and cells respond to different thresholds of Hh with distinct responses. The cellular machinery that is responsible for the unique molecular mechanisms of Hh signal transduction has been largely conserved during metazoan evolution.

Related Organizations

University of Colorado Cancer Center
United States
Stanford University
United States
University of Colorado Denver
United States
Howard Hughes Medical Institute
United States

Keywords

Kinesins, Ligands, Receptors, G-Protein-Coupled, Evolution, Molecular, Wnt Proteins, Drosophila melanogaster, Trans-Activators, Animals, Drosophila Proteins, Humans, Intercellular Signaling Peptides and Proteins, Hedgehog Proteins, Signal Transduction

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