Checking on DNA damage in S phase
Copyright policy )Checking on DNA damage in S phase
The precise replication of the genome and the continuous surveillance of its integrity are essential for survival and the avoidance of various diseases. Cells respond to DNA damage by activating a complex network of the so-called checkpoint pathways to delay their cell-cycle progression and repair the defects. In this review we integrate findings on the emerging mechanisms of activation, the signalling pathways and the spatio-temporal organization of the intra-S-phase DNA-damage checkpoint and its impact on the cell-cycle machinery, and discuss its biological significance.
- Danish Cancer Society Denmark
Time Factors, Tumor Suppressor Proteins, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins, Protein Serine-Threonine Kinases, Cell Line, S Phase, DNA-Binding Proteins, Enzyme Activation, Genes, cdc, Checkpoint Kinase 2, Checkpoint Kinase 1, Animals, Humans, cdc25 Phosphatases, Protein Kinases, DNA Damage, Signal Transduction
Time Factors, Tumor Suppressor Proteins, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins, Protein Serine-Threonine Kinases, Cell Line, S Phase, DNA-Binding Proteins, Enzyme Activation, Genes, cdc, Checkpoint Kinase 2, Checkpoint Kinase 1, Animals, Humans, cdc25 Phosphatases, Protein Kinases, DNA Damage, Signal Transduction
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