Oxygen sensing by HIF hydroxylases
Copyright policy )Oxygen sensing by HIF hydroxylases
The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen homeostasis in animals ranging from nematode worms to man. Recent studies have shown that this factor is regulated by an unprecedented signalling mechanism that involves post-translational hydroxylation. This hydroxylation is catalysed by a set of non-haem, Fe2+-dependent enzymes that belong to the 2-oxoglutarate-dependent-oxygenase superfamily. The absolute requirement of these enzymes for molecular oxygen has provided new insights into the way cells sense oxygen.
- University of Oxford United Kingdom
Oxygen, Gene Expression Regulation, Oxygenases, Animals, Humans, Ketoglutaric Acids, Hydroxylation, Hypoxia-Inducible Factor 1, alpha Subunit, Cell Hypoxia, Transcription Factors
Oxygen, Gene Expression Regulation, Oxygenases, Animals, Humans, Ketoglutaric Acids, Hydroxylation, Hypoxia-Inducible Factor 1, alpha Subunit, Cell Hypoxia, Transcription Factors
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).2K popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 0.1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 0.1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%
Citations provided by BIP!Popularity provided by BIP!