Mechanism and regulation of human non-homologous DNA end-joining
Copyright policy )Mechanism and regulation of human non-homologous DNA end-joining
Non-homologous DNA end-joining (NHEJ)--the main pathway for repairing double-stranded DNA breaks--functions throughout the cell cycle to repair such lesions. Defects in NHEJ result in marked sensitivity to ionizing radiation and ablation of lymphocytes, which rely on NHEJ to complete the rearrangement of antigen-receptor genes. NHEJ is typically imprecise, a characteristic that is useful for immune diversification in lymphocytes, but which might also contribute to some of the genetic changes that underlie cancer and ageing.
- University of Ulm Germany
- Keck Hospital of USC United States
- USC Norris Cancer Hospital United States
- University of California System United States
- University of Southern California United States
DNA-Binding Proteins, Gene Rearrangement, DNA Repair, Animals, Humans, Nuclear Proteins, Endonucleases, DNA Damage
DNA-Binding Proteins, Gene Rearrangement, DNA Repair, Animals, Humans, Nuclear Proteins, Endonucleases, DNA Damage
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