Titin: properties and family relationships

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2003 English Publisher:Springer Science and Business Media LLCJournal:Nature Reviews Molecular Cell Biology, volume 4, pages 679-689 (issn: 1471-0072, eissn: 1471-0080,

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Authors: Larissa, Tskhovrebova; John, Trinick;

doi: 10.1038/nrm1198

pmid: 14506471

Titin: properties and family relationships

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Abstract

In striated muscles, the rapid production of macroscopic levels of force and displacement stems directly from highly ordered and hierarchical protein organization, with the sarcomere as the elemental contractile unit. There is now a wealth of evidence indicating that the giant elastic protein titin has important roles in controlling the structure and extensibility of vertebrate muscle sarcomeres.

Related Organizations

University of Leeds
United Kingdom

Keywords

Sarcomeres, Microscopy, Electron, Multigene Family, Animals, Humans, Muscle Proteins, Connectin, Muscle, Skeletal, Protein Kinases, Cytoskeleton

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