Replicating by the clock

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2003 English Publisher:Springer Science and Business Media LLCJournal:Nature Reviews Molecular Cell Biology, volume 4, pages 25-32 (issn: 1471-0072, eissn: 1471-0080,

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Authors: Alon, Goren; Howard, Cedar;

doi: 10.1038/nrm1008

pmid: 12511866

Replicating by the clock

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Abstract

The eukaryotic genome is divided into well-defined DNA regions that are programmed to replicate at different times during S phase. Active genes are generally associated with early replication, whereas inactive genes replicate late. This expression pattern might be facilitated by the differential restructuring of chromatin at the time of replication in early or late S phase.

Related Organizations

Hebrew University of Jerusalem
Israel

Keywords

DNA Replication, Genome, Time Factors, Gene Expression Regulation, Animals, Humans, Chromatin, S Phase

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