descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 24 Aug 2016 English Publisher:Springer Science and Business Media LLCJournal:Nature Reviews Molecular Cell Biology, volume 17, pages 605-606 (issn: 1471-0072, eissn: 1471-0080,

Authors: Ody C. M. Sibon; Erick Strauss;

doi: 10.1038/nrm.2016.110

pmid: 27552973

handle: 11370/6d5ab248-3eed-48dd-9ccf-7e1a7f29919b

Coenzyme A: to make it or uptake it?

- Summary
- Subjects
- Metrics

Abstract

The consensus has been that intracellular coenzyme A (CoA) is obtained exclusively by de novo biosynthesis via a universal, conserved five-step pathway in the cell cytosol. However, old and new evidence suggest that cells (and some microorganisms) have several strategies to obtain CoA, with 4'-phosphopantetheine (P-PantSH; the fourth intermediate in the canonical CoA biosynthetic pathway) serving as a 'nexus' metabolite.

Related Organizations

University Medical Center Groningen
Netherlands
Stellenbosch University
South Africa
University of Groningen
Netherlands
University Medical Center Groningen
Netherlands

Keywords

Cell Membrane Permeability, TRANSPORTER, 4-PHOSPHOPANTETHEINE, Biological Transport, METABOLISM, Biosynthetic Pathways, ESCHERICHIA-COLI, Pantetheine, Animals, Humans, Coenzyme A

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	60
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%