Humanized mice in translational biomedical research
Copyright policy )Humanized mice in translational biomedical research
The culmination of decades of research on humanized mice is leading to advances in our understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity, infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss the development of these new generations of humanized mice, how they will facilitate translational research in several biomedical disciplines and approaches to overcome the remaining limitations of these models.
- RIKEN Japan
- Jackson Laboratory United States
- University of Massachusetts Medical School United States
Mice, Knockout, Chimera, 610, Mice, Transgenic, Mice, SCID, Mice-Knockout, Communicable Diseases, Mice-Transgenic, Hematopoiesis, Communicable-Diseases, Disease Models, Animal, Mice, Neoplasms, Mice-SCID, 616, Animals, Humans, Disease-Models-Animal
Mice, Knockout, Chimera, 610, Mice, Transgenic, Mice, SCID, Mice-Knockout, Communicable Diseases, Mice-Transgenic, Hematopoiesis, Communicable-Diseases, Disease Models, Animal, Mice, Neoplasms, Mice-SCID, 616, Animals, Humans, Disease-Models-Animal
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