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Heterochromatin revisited

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2007 English Publisher:Springer Science and Business Media LLCJournal:Nature Reviews Genetics, volume 8, pages 35-46 (issn: 1471-0056, eissn: 1471-0064, Copyright policy )Funded by:UKRI | Future Flight 2022 - 2024
Authors: Grewal, Shiv I. S.; Jia, Songtao;

doi: 10.1038/nrg2008

pmid: 17173056

Heterochromatin revisited

Abstract

The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and the subsequent recruitment of chromodomain proteins such as heterochromatin protein HP1, serves as a model for the role of histone modifications and chromatin assembly in epigenetic control of the genome. Recent studies in Schizosaccharomyces pombe indicate that heterochromatin serves as a dynamic platform to recruit and spread a myriad of regulatory proteins across extended domains to control various chromosomal processes, including transcription, chromosome segregation and long-range chromatin interactions.

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Keywords

Mammals, Models, Genetic, Chromosomal Proteins, Non-Histone, Plants, Chromatin Assembly and Disassembly, Epigenesis, Genetic, Histones, Chromobox Protein Homolog 5, Heterochromatin, Schizosaccharomyces, Animals, RNA Interference, Schizosaccharomyces pombe Proteins, Ciliophora

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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