Oncolytic viruses

Name: Oncolytic viruses
Creator: E Antonio, Chiocca
Keywords: 0301 basic medicine, Clinical Trials as Topic, 0303 health sciences, Cell- and Tissue-Based Therapy, Antineoplastic Agents, Virus Replication, 3. Good health, 03 medical and health sciences, Organ Specificity, Neoplasms

E Antonio, Chiocca

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Nature Reviews Cance...arrow_drop_down

Nature Reviews Cancer

Article . 2002 . Peer-reviewed

License: Springer TDM

Data sources: Crossref

https://pubmed.ncbi.nlm.nih.go...

Article . 2003

Data sources: Europe PubMed Central

Oncolytic viruses

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2002 English Publisher:Springer Science and Business Media LLCJournal:Nature Reviews Cancer, volume 2, pages 938-950 (issn: 1474-175X, eissn: 1474-1768,

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Authors: E Antonio, Chiocca;

doi: 10.1038/nrc948

pmid: 12459732

Oncolytic viruses

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Abstract

Although the cytotoxic effects of viruses are usually viewed in terms of pathogenicity, it is possible to harness this activity for therapeutic purposes. Viral genomes are highly versatile, and can be modified to direct their cytotoxicity towards cancer cells. These viruses are known as oncolytic viruses. How are viruses engineered to become tumour specific, and can they be used to safely treat cancer in humans?

Related Organizations

Massachusetts General Hospital
United States

Keywords

Clinical Trials as Topic, Cell- and Tissue-Based Therapy, Antineoplastic Agents, Virus Replication, Organ Specificity, Neoplasms, Viruses, Animals, Humans, Genetic Engineering, Virus Physiological Phenomena

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