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Mutant relationships

Name: Mutant relationships
Creator: Sarah Seton-Rogers
Keywords: DNA-Binding Proteins, Homeodomain Proteins, 0301 basic medicine, 03 medical and health sciences, 0302 clinical medicine, Models, Chemical, Humans, Nuclear Proteins, 3. Good health

descriptionPublicationkeyboard_double_arrow_right Article 12 Feb 2015 English Publisher:Springer Science and Business Media LLCJournal:Nature Reviews Cancer, volume 15, pages 135-135 (issn: 1474-175X, eissn: 1474-1768,

Authors: Sarah Seton-Rogers;

doi: 10.1038/nrc3917

pmid: 25673084

Mutant relationships

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Abstract

Stites and Trampont et al. used mathematical modelling with verification in cells and cancer genome data to understand the effects of weakly activating RAS mutations. They found that pairs of mutations within the RAS pathway might be able to act together to create a selective advantage in human tumours.

Keywords

DNA-Binding Proteins, Homeodomain Proteins, Models, Chemical, Humans, Nuclear Proteins

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	1
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average