<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

Kinesins and cancer

descriptionPublicationkeyboard_double_arrow_right Article 24 Jul 2012 English Publisher:Springer Science and Business Media LLCJournal:Nature Reviews Cancer, volume 12, pages 527-539 (issn: 1474-175X, eissn: 1474-1768,

Authors: Frank Kozielski; Oliver Rath;

doi: 10.1038/nrc3310

pmid: 22825217

Kinesins and cancer

- Summary
- Subjects
- External Databases
  (1)
- Metrics

Abstract

Kinesins are a family of molecular motors that travel unidirectionally along microtubule tracks to fulfil their many roles in intracellular transport or cell division. Over the past few years kinesins that are involved in mitosis have emerged as potential targets for cancer drug development. Several compounds that inhibit two mitotic kinesins (EG5 (also known as KIF11) and centromere-associated protein E (CENPE)) have entered Phase I and II clinical trials either as monotherapies or in combination with other drugs. Additional mitotic kinesins are currently being validated as drug targets, raising the possibility that the range of kinesin-based drug targets may expand in the future.

Related Organizations

Cancer Research UK Scotland Institute
United Kingdom

Keywords

Clinical Trials, Phase II as Topic, Clinical Trials, Phase I as Topic, Neoplasms, Drug Evaluation, Preclinical, Animals, Humans, Kinesins, Mitosis, Antineoplastic Agents

2rep

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	448
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 0.1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%