
doi: 10.1038/nrc2541
pmid: 19052556
Toll-like receptors (TLRs) are a family of pattern recognition receptors that are best-known for their role in host defence from infection. Emerging evidence also suggests that TLRs have an important role in maintaining tissue homeostasis by regulating the inflammatory and tissue repair responses to injury. The development of cancer has been associated with microbial infection, injury, inflammation and tissue repair. Here we discuss how the function of TLRs may relate to these processes in the context of carcinogenesis.
Inflammation, Wound Healing, Toll-Like Receptors, Infections, Ligands, Immunotherapy, Adoptive, Neoplasm Proteins, Mice, Cell Transformation, Neoplastic, T-Lymphocyte Subsets, Neoplasms, Myeloid Differentiation Factor 88, Animals, Homeostasis, Humans, Regeneration, Immunologic Surveillance, Signal Transduction
Inflammation, Wound Healing, Toll-Like Receptors, Infections, Ligands, Immunotherapy, Adoptive, Neoplasm Proteins, Mice, Cell Transformation, Neoplastic, T-Lymphocyte Subsets, Neoplasms, Myeloid Differentiation Factor 88, Animals, Homeostasis, Humans, Regeneration, Immunologic Surveillance, Signal Transduction
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