Maximizing mouse cancer models

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2007 English Publisher:Springer Science and Business Media LLCJournal:Nature Reviews Cancer, volume 7, pages 654-658 (issn: 1474-175X, eissn: 1474-1768,

Copyright policy )Funded by:NIH | Mutant mouse models of ex..., NIH | Lineage Tracy in Murine P...

Authors: Kristopher K, Frese; David A, Tuveson;

doi: 10.1038/nrc2192

pmid: 17687385

Maximizing mouse cancer models

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Abstract

Animal models of cancer provide an alternative means to determine the causes of and treatments for malignancy, thus representing a resource of immense potential for cancer medicine. The sophistication of modelling cancer in mice has increased to the extent that investigators can both observe and manipulate a complex disease process in a manner impossible to perform in patients. However, owing to limitations in model design and technology development, and the surprising underuse of existing models, only now are we realising the full potential of mouse models of cancer and what new approaches are needed to derive the maximum value for cancer patients from this investment.

Related Organizations

University of Cambridge
United Kingdom
Cancer Research UK
United Kingdom

Keywords

Mice, Transgenic, Oncogenes, Medical Oncology, Animals, Genetically Modified, Disease Models, Animal, Mice, Neoplasms, Models, Animal, Animals, Humans, Genes, Tumor Suppressor, Neoplasm Transplantation

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