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In vivo models of proliferative vitreoretinopathy

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2007 English Publisher:Springer Science and Business Media LLCJournal:Nature Protocols, volume 2, pages 67-77 (issn: 1754-2189, eissn: 1750-2799,

Authors: David R. Hinton; Rajat Agrawal; Jing Z Cui; Stephen J. Ryan; Christine Spee; Shikun He;

doi: 10.1038/nprot.2007.4

pmid: 17401340

In vivo models of proliferative vitreoretinopathy

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Abstract

We outline current in vitro and in vivo models for experimental proliferative vitreoretinopathy (PVR) and provide a detailed protocol of our standardized in vivo PVR model. PVR is the leading cause of failed surgical procedures for the correction of rhegmatogenous retinal detachment. The pathogenesis of this multifactorial condition is still not completely understood. Experimental models for PVR help us understand the factors that play a role in the pathogenesis of the disease process in a controlled manner and allow for reproducible preclinical assessment of novel therapeutic interventions. We describe a cell injection model in detail that uses homologous retinal pigment epithelial (RPE) cell cultures to induce PVR over a 2-8 week period.

Related Organizations

University of California System
United States
University of British Columbia
Canada

Keywords

Models, Animal, Vitreoretinopathy, Proliferative, Animals, Rabbits, Fluorescein Angiography, Pigment Epithelium of Eye, Cells, Cultured, Tomography, Optical Coherence, Injections

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	105
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%