Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice
Copyright policy )Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice
Blockade of cholinergic neurotransmission by muscarinic receptor antagonists produces profound deficits in attention and memory. However, the antagonists used in previous studies bind to more than one of the five muscarinic receptor subtypes. Here we examined memory in mice with a null mutation of the gene coding the M1 receptor, the most densely distributed muscarinic receptor in the hippocampus and forebrain. In contrast with previous studies using nonselective pharmacological antagonists, the M1 receptor deletion produced a selective phenotype that included both enhancements and deficits in memory. Long-term potentiation (LTP) in response to theta burst stimulation in the hippocampus was also reduced in mutant mice. M1 null mutant mice showed normal or enhanced memory for tasks that involved matching-to-sample problems, but they were severely impaired in non-matching-to-sample working memory as well as consolidation. Our results suggest that the M1 receptor is specifically involved in memory processes for which the cortex and hippocampus interact.
- University of Washington United States
- University of California, Los Angeles United States
- Emory University United States
- University of Mary United States
Cerebral Cortex, Male, Mice, Knockout, Memory Disorders, Fear, Hippocampus, Acetylcholine, Electric Stimulation, Discrimination Learning, Mice, Memory, Short-Term, Phenotype, Memory, Conditioning, Psychological, Mutation, Neural Pathways, Animals, Female, Cues, Maze Learning
Cerebral Cortex, Male, Mice, Knockout, Memory Disorders, Fear, Hippocampus, Acetylcholine, Electric Stimulation, Discrimination Learning, Mice, Memory, Short-Term, Phenotype, Memory, Conditioning, Psychological, Mutation, Neural Pathways, Animals, Female, Cues, Maze Learning
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).499 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!