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A developmental switch in the signaling cascades for LTP induction

descriptionPublicationkeyboard_double_arrow_right Article 02 Dec 2002Publisher:Springer Science and Business Media LLCJournal:Nature Neuroscience, volume 6, pages 15-16 (issn: 1097-6256, eissn: 1546-1726,

Authors: Alison L. Barth; Robert C. Malenka; David Stellwagen; Hiroki Yasuda;

doi: 10.1038/nn985

pmid: 12469130

A developmental switch in the signaling cascades for LTP induction

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Abstract

Long-term potentiation (LTP) is thought to be critically involved not only in learning and memory, but also during the activity-dependent developmental phases of neural circuit formation and refinement. Whether the mechanisms underlying LTP change during this phase of postnatal development, however, is unknown. We report here that, unlike LTP in the more mature CA1 region of the hippocampus, LTP in neonatal rodent hippocampus (<9 postnatal days,

Related Organizations

Stanford University
United States

Keywords

Mitogen-Activated Protein Kinase 1, Neurons, Dose-Response Relationship, Drug, Colforsin, Long-Term Potentiation, Intracellular Signaling Peptides and Proteins, Excitatory Postsynaptic Potentials, Cyclic AMP-Dependent Protein Kinases, Hippocampus, Peptide Fragments, Rats, Animals, Newborn, Calcium-Calmodulin-Dependent Protein Kinases, Mutation, Neural Pathways, Animals, Enzyme Inhibitors, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Carrier Proteins, Signal Transduction

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