Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition
Copyright policy )Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition
Fear conditioning involves the induction of long-term potentiation (LTP) of excitatory synaptic transmission in the lateral amygdala, a brain structure which is tightly controlled by GABAergic inhibition. Here we show that dopamine gates the induction of LTP in the mouse lateral amygdala by suppressing feedforward inhibition from local interneurons. Our findings provide a cellular mechanism for the dopaminergic modulation of fear conditioning and indicate that suppression of feedforward inhibition represents a key mechanism for the induction of associative synaptic plasticity in the lateral amygdala.
- University of Basel Switzerland
Male, Dopamine, Long-Term Potentiation, Excitatory Postsynaptic Potentials, Neural Inhibition, Fear, Amygdala, Synaptic Transmission, Receptors, Dopamine, GABA Antagonists, Mice, Inbred C57BL, Mice, Organ Culture Techniques, Interneurons, Conditioning, Psychological, Dopamine Agonists, Neural Pathways, Animals, Dopamine Antagonists, Learning, gamma-Aminobutyric Acid
Male, Dopamine, Long-Term Potentiation, Excitatory Postsynaptic Potentials, Neural Inhibition, Fear, Amygdala, Synaptic Transmission, Receptors, Dopamine, GABA Antagonists, Mice, Inbred C57BL, Mice, Organ Culture Techniques, Interneurons, Conditioning, Psychological, Dopamine Agonists, Neural Pathways, Animals, Dopamine Antagonists, Learning, gamma-Aminobutyric Acid
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).369 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!