Necroptosis activation in Alzheimer's disease
Copyright policy )Necroptosis activation in Alzheimer's disease
Alzheimer's disease (AD) is characterized by severe neuronal loss; however, the mechanisms by which neurons die remain elusive. Necroptosis, a programmed form of necrosis, is executed by the mixed lineage kinase domain-like (MLKL) protein, which is triggered by receptor-interactive protein kinases (RIPK) 1 and 3. We found that necroptosis was activated in postmortem human AD brains, positively correlated with Braak stage, and inversely correlated with brain weight and cognitive scores. In addition, we found that the set of genes regulated by RIPK1 overlapped significantly with multiple independent AD transcriptomic signatures, indicating that RIPK1 activity could explain a substantial portion of transcriptomic changes in AD. Furthermore, we observed that lowering necroptosis activation reduced cell loss in a mouse model of AD. We anticipate that our findings will spur a new area of research in the AD field focused on developing new therapeutic strategies aimed at blocking its activation.
- University of California, Irvine United States
- University of Catania Italy
- University of Messina Italy
- Translational Genomics Research Institute United States
- Icahn School of Medicine at Mount Sinai United States
Mice, Knockout, Mice, 129 Strain, Apoptosis, Mice, Transgenic, Temporal Lobe, Mice, Inbred C57BL, Mice, Necrosis, Random Allocation, Alzheimer Disease, Animals, Humans, Maze Learning, Cells, Cultured
Mice, Knockout, Mice, 129 Strain, Apoptosis, Mice, Transgenic, Temporal Lobe, Mice, Inbred C57BL, Mice, Necrosis, Random Allocation, Alzheimer Disease, Animals, Humans, Maze Learning, Cells, Cultured
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