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Other literature type . 2016
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Nature Neuroscience
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Nature Neuroscience
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https://dx.doi.org/10.1038/nn....
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Biophysical constraints of optogenetic inhibition at presynaptic terminals

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 07 Mar 2016 English Publisher:Springer Science and Business Media LLCJournal:Nature Neuroscience, volume 19, pages 554-556 (issn: 1097-6256, eissn: 1546-1726, Copyright policy )Funded by:EC | OPTONEUROMOD, EC | HIPPOFRONTALSYN
Authors: Mathias Mahn; Matthias Prigge; Shiri Ron; Rivka Levy; Ofer Yizhar;

doi: 10.1038/nn.4266

pmid: 26950004

pmc: PMC4926958

Biophysical constraints of optogenetic inhibition at presynaptic terminals

Abstract

We investigated the efficacy of optogenetic inhibition at presynaptic terminals using halorhodopsin, archaerhodopsin and chloride-conducting channelrhodopsins. Precisely timed activation of both archaerhodopsin and halorhodpsin at presynaptic terminals attenuated evoked release. However, sustained archaerhodopsin activation was paradoxically associated with increased spontaneous release. Activation of chloride-conducting channelrhodopsins triggered neurotransmitter release upon light onset. Thus, the biophysical properties of presynaptic terminals dictate unique boundary conditions for optogenetic manipulation.

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Keywords

Male, Presynaptic Terminals, Neural Inhibition, Hippocampus, Synaptic Transmission, Article, Biophysical Phenomena, Rats, Mice, Inbred C57BL, Optogenetics, Rats, Sprague-Dawley, Mice, HEK293 Cells, Organ Culture Techniques, Animals, Humans, Female, Halorhodopsins, Cells, Cultured

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 319
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
319
Top 1%
Top 10%
Top 0.1%
Green
hybrid
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Neuroscience